Description

Perfluorophenyl 3-(Pyridin-2-Yldisulfanyl)Propanoate is a specialized organosulfur and organofluorine compound featuring a cleavable disulfide linker. This molecular architecture is critical for its role as a versatile bioconjugation and cross-linking reagent in advanced chemical synthesis. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of targeted drug delivery systems, antibody-drug conjugates (ADCs), and protein modification.

Application

• Bioconjugation Reagent: For site-specific modification of proteins, peptides, and antibodies via disulfide bond formation.
• Antibody-Drug Conjugate (ADC) Linker: Serves as a cleavable linker connecting cytotoxic payloads to monoclonal antibodies for targeted cancer therapies.
• Prodrug Synthesis: Used in the design of prodrugs where the active agent is released upon reduction of the disulfide bond in specific physiological environments.
• Polymer Functionalization: Enables the introduction of pyridyl disulfide groups onto polymer backbones for creating stimuli-responsive materials.
• Surface Immobilization: Facilitates the controlled attachment of biomolecules onto gold nanoparticles or biosensor surfaces through thiol-disulfide exchange.
• Chemical Biology Tool: Employed in studying protein-protein interactions and cellular uptake mechanisms via reversible linkage.

Basic Information

Product Name	Perfluorophenyl 3-(Pyridin-2-Yldisulfanyl)Propanoate
CAS No.	160580-70-1
Molecular Formula	C14H5F5NO2S2
Molecular Weight	399.32 g/mol
Synonyms	2,3,4,5,6-Pentafluorophenyl 3-(2-pyridyldithio)propionate; PDPP; Pentafluorophenyl 3-(2-pyridyldithio)propanoate; 3-(2-Pyridyldithio)propionic Acid Pentafluorophenyl Ester; PFP-PDP; Pentafluorophenyl PDP Ester; PFP-S-S-Py; N-(Pentafluorophenyl)-3-(2-pyridyldithio)propionamide (common misnomer)
EINECS	Contact for details

Quality Control

Our Perfluorophenyl 3-(Pyridin-2-Yldisulfanyl)Propanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and bioconjugation applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee reproducible performance and supply chain reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. The material is light-sensitive and moisture-sensitive; allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to pale yellow crystalline solid or powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area Percent)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.