Description

14-Deoxy-11-Hydroxyandrographolide is a key diterpenoid lactone derivative, primarily known for its role as a significant metabolite and intermediate in the synthesis of bioactive compounds. This high-purity chemical is valued for its structural specificity, which is crucial for research into novel therapeutic agents and for ensuring batch-to-batch consistency in advanced manufacturing. It is essential for pharmaceutical R&D laboratories, nutraceutical formulators, and academic institutions focused on anti-inflammatory and hepatoprotective agent development.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel andrographolide analogs with targeted bioactivity.
• Reference Standard: Used as a high-purity analytical standard in HPLC and LC-MS for quality control of herbal extracts and finished products containing Andrographis paniculata.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate structure-activity relationships (SAR) and metabolic pathways of diterpenoids.
• Nutraceutical Development: Incorporated into advanced supplement formulations aiming for standardized, potent extracts with consistent pharmacological profiles.
• Academic Research: A key compound for studies in natural product chemistry, phytopharmacology, and medicinal chemistry.

Basic Information

Product Name	14-Deoxy-11-Hydroxyandrographolide
CAS No.	160242-09-1
Molecular Formula	C₂₀H₃₀O₅
Molecular Weight	350.45 g/mol
Synonyms	14-Deoxy-11-hydroxyandrographolide; 11-Hydroxy-14-deoxyandrographolide; 3-[2-[Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone; Andrographolide, 14-deoxy-11-hydroxy-; 14-Deoxy-11β-hydroxyandrographolide
EINECS	Contact for details

Quality Control

Our 14-Deoxy-11-Hydroxyandrographolide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.