Description

[(1S,2R)-3-[[(4-Nitrophenyl)Sulfonyl](2-Methylpropyl)Amino]-2-Hydroxy-1-Phenylmethyl)Propyl]Carbamic Acid, (3S)-Tetrahydro-3-Furanyl Ester is a sophisticated chiral organic compound with a complex molecular architecture, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in enabling the precise construction of high-value target molecules, particularly in the pharmaceutical sector where stereochemical control is paramount. This compound is essential for research chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially in therapeutic areas requiring complex, multi-functional molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, cardiovascular diseases, or anti-infective agents.
• Protease Inhibitor Research: The structural motifs suggest potential utility in the development of protease inhibitors, making it valuable for antiviral and anticancer drug discovery programs.
• Chiral Auxiliary/Synthon: Used as a chiral synthon to introduce specific stereocenters and functional groups (e.g., carbamate, sulfonamide) into more complex molecular frameworks with high enantiomeric purity.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization studies for the commercial-scale production of target APIs, where its defined stereochemistry ensures batch-to-batch consistency.
• Academic & Institutional Research: Serves as a substrate or intermediate in methodological studies exploring new asymmetric synthesis techniques, catalysis, or molecular recognition.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific molecules under cGMP or non-GMP conditions.

Basic Information

Product Name	[(1S,2R)-3-[[(4-Nitrophenyl)Sulfonyl](2-Methylpropyl)Amino]-2-Hydroxy-1-Phenylmethyl)Propyl]Carbamic Acid, (3S)-Tetrahydro-3-Furanyl Ester
CAS No.	160231-69-6
Molecular Formula	C25H33N3O7S
Molecular Weight	519.61 g/mol
Synonyms	(3S)-Tetrahydro-3-furanyl N-[(1S,2R)-3-[[(4-nitrophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamate; (1S,2R)-3-[[(4-Nitrophenyl)sulfonyl](isobutyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3S)-tetrahydro-3-furanyl ester; UNII-8V8T6Q6V6C; 8V8T6Q6V6C; AT7519 Impurity; AT7519 Intermediate; Isobutyl(4-nitrophenyl)sulfonamide derivative; Chiral Sulfonamide Carbamate Ester
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and analyzed under strict quality management systems. We provide comprehensive analytical data to support your research and development, including HPLC purity (typically ≥97%), chiral purity (enantiomeric excess), and confirmation of structure via spectroscopic methods. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting identity, purity, and impurity profiles. Our quality commitment aligns with the standards expected for pharmaceutical R&D, and we can support development toward cGMP-grade material as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.