Description

2,2,2-Trifluoro-1-(4-(4-Nitrophenyl)Piperidin-1-Yl)Ethanone is a specialized fluorinated organic compound featuring a trifluoroacetyl group linked to a 4-(4-nitrophenyl)piperidine scaffold. This structure makes it a valuable high-purity building block and key intermediate in advanced synthetic chemistry. It is primarily utilized by research institutions and pharmaceutical development companies engaged in the discovery of novel bioactive molecules, particularly within medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products, leveraging its fluorinated aromatic structure.
• Material Science: Acts as a monomer or functionalization agent in the creation of specialty polymers with unique electronic or surface properties.
• Chemical Biology: Employed as a probe or labeling reagent due to the reactivity of the trifluoroacetyl ketone and the spectroscopic handle provided by the nitro group.
• Academic & Contract Research: Essential for methodological development in organic synthesis, including studies on fluorination, piperidine chemistry, and cross-coupling reactions.

Basic Information

Item	Detail
Product Name	2,2,2-Trifluoro-1-(4-(4-Nitrophenyl)Piperidin-1-Yl)Ethanone
CAS No.	160132-86-5
Molecular Formula	C13H13F3N2O3
Molecular Weight	302.25 g/mol
Synonyms	1-[4-(4-Nitrophenyl)-1-piperidinyl]-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-[4-(4-nitrophenyl)-1-piperidinyl]ethanone; 4-(4-Nitrophenyl)-1-(2,2,2-trifluoroacetyl)piperidine; 1-(4-(4-Nitrophenyl)piperidin-1-yl)-2,2,2-trifluoroethanone; Trifluoroacetyl 4-(4-nitrophenyl)piperidine; TFAPE; TFPNE
EINECS	Contact for details

Quality Control

Our production of 2,2,2-Trifluoro-1-(4-(4-Nitrophenyl)Piperidin-1-Yl)Ethanone adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and GC-MS for solvent residue analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat sources and incompatible materials. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.