Description

2,6-Methano-1H-Pyrrolizine-1-Carbonitrile,Hexahydro-,[1R-(1Alpha,2Beta,6Beta,7Abeta)]- is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is valued for its complex, rigid polycyclic structure, which serves as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within the fields of neurology and complex organic synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates and proprietary APIs.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its constrained three-dimensional geometry.
• Asymmetric Synthesis: Serves as a precursor or template in catalytic asymmetric reactions to introduce specific stereocenters.
• Neurological Drug Development: Potential building block for compounds targeting specific receptors in the central nervous system.
• Process Chemistry Scale-Up: Supplied for route scouting and optimization from milligram to kilogram scale for clinical trial material production.
• Reference Standard: Used as a high-purity analytical standard for method development and quality control in API manufacturing.

Basic Information

Product Name	2,6-Methano-1H-Pyrrolizine-1-Carbonitrile,Hexahydro-,[1R-(1Alpha,2Beta,6Beta,7Abeta)]-
CAS No.	160080-10-4
Molecular Formula	C10H14N2
Molecular Weight	162.23 g/mol
Synonyms	(1R,2R,6R,7aR)-Hexahydro-2,6-methano-1H-pyrrolizine-1-carbonitrile; (1R,2R,6R,7aR)-Octahydro-2,6-methanocyclopenta[b]pyrrol-1-carbonitrile; [1R-(1α,2β,6β,7aβ)]-Hexahydro-2,6-methano-1H-pyrrolizine-1-carbonitrile; 1-Cyanohexahydro-2,6-methano-1H-pyrrolizine; 2,6-Methano-1H-pyrrolizine-1-carbonitrile, hexahydro-, (1R,2R,6R,7aR)-rel-; Advanced Pyrrolizine Nitrile Intermediate
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles to ensure it meets the exacting standards required for pharmaceutical R&D and scale-up. Our quality protocols are designed to support GMP (Good Manufacturing Practice) compliance for drug substance manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.