Description

1-Azabicyclo(2.2.2)Octane-3-Acetonitrile, α-(Methoxyimino)-, Monohydrochloride, (R-(Z))- is a high-purity, stereochemically defined pharmaceutical intermediate of significant commercial importance. This compound is valued for its role as a key chiral building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the global pharmaceutical and fine chemical industries for the development and production of advanced therapeutics.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of complex drug molecules, particularly those targeting the central nervous system.
• API Synthesis: Used as a key precursor in the manufacturing route for specific active pharmaceutical ingredients requiring its unique bicyclic quinuclidine structure.
• Medicinal Chemistry Research: Employed in R&D laboratories for structure-activity relationship (SAR) studies and the discovery of new chemical entities.
• Asymmetric Synthesis: Utilized in reactions where its defined (R)-(Z) stereochemistry is essential for inducing chirality in final target molecules.
• Process Chemistry Development: Serves as a standard or starting material for scaling up and optimizing synthetic pathways in pilot plants and commercial production.

Basic Information

Product Name	1-Azabicyclo(2.2.2)Octane-3-Acetonitrile, α-(Methoxyimino)-, Monohydrochloride, (R-(Z))-
CAS No.	159912-58-0
Molecular Formula	C10H16N3O·HCl
Molecular Weight	231.72 g/mol (free base: 195.26 g/mol)
Synonyms	(R,Z)-3-[(Methoxyimino)(quinuclidin-3-yl)methyl]acetonitrile hydrochloride; (3R)-3-[(Z)-2-Cyano-1-(methoxyimino)ethyl]quinuclidine hydrochloride; Quinuclidine-3-acetonitrile, α-(methoxyimino)-, monohydrochloride, (R-(Z))-; (R)-(Z)-α-(Methoxyimino)quinuclidine-3-acetonitrile hydrochloride; 159912-58-0; (R,Z)-Quinuclidin-3-yl(methoxyimino)acetonitrile hydrochloride
EINECS	Contact for details

Quality Control

Our production of 1-Azabicyclo(2.2.2)Octane-3-Acetonitrile, α-(Methoxyimino)-, Monohydrochloride, (R-(Z))- adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and related substances are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (R,Z)-isomer
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.