Description

1-[3-(Pentafluorosulphanyl)Phenyl]Ethan-1-One, also known as 3-Acetylphenylsulphur Pentafluoride, is a high-value organofluorine building block characterized by its unique pentafluorosulfanyl (SF5) functional group. This compound matters for its role in enhancing the physicochemical properties of target molecules, offering significant potential to improve metabolic stability, lipophilicity, and overall bioactivity in advanced chemical synthesis. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, as well as by specialty chemical manufacturers developing advanced materials and ligands for catalysis.

Application

• Pharmaceutical Intermediate: A key synthon for introducing the metabolically stable SF5 group into drug candidates, potentially improving their pharmacokinetic profiles.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides where the SF5 moiety can enhance biological activity and environmental persistence.
• Material Science: Serves as a precursor for advanced polymers, liquid crystals, and electronic materials requiring specific fluorine content for desired thermal and electronic properties.
• Catalysis & Ligand Design: Employed in the development of novel ligands for transition metal catalysis, leveraging the strong electron-withdrawing nature of the SF5 group.
• Life Science Probes: Utilized in medicinal chemistry for creating labeled compounds and molecular probes for imaging and diagnostic applications.

Basic Information

Product Name	1-[3-(Pentafluorosulphanyl)Phenyl]Ethan-1-One
CAS No.	159896-31-8
Molecular Formula	C8H5F5OS
Molecular Weight	244.18 g/mol
Synonyms	3-Acetylphenylsulphur Pentafluoride; 3-Acetylphenyl Sulfur Pentafluoride; 1-[3-(SF5)Phenyl]Ethanone; 3-Acetylbenzenesulfonyl Fluoride Pentafluoride; 3'-Acetylphenylsulfur Pentafluoride; Ethanone, 1-[3-(pentafluorosulfanyl)phenyl]-; 3-Acetylphenyl SF5
EINECS	Contact for details

Quality Control

Our 1-[3-(Pentafluorosulphanyl)Phenyl]Ethan-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.