Description

1-(2,3-Epoxypropyl)-4-tert-Butoxycarbonylpiperazine is a specialized bifunctional building block that combines a reactive epoxide group with a protected piperazine amine. This molecular architecture makes it a critical intermediate for the synthesis of complex molecules, particularly in advanced pharmaceutical research and development. It is primarily sought after by pharmaceutical companies, contract research organizations (CROs), and fine chemical manufacturers engaged in creating novel active pharmaceutical ingredients (APIs) and other high-value compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology, neurology, and anti-infective therapeutic areas.
• Linker Chemistry: Used to create molecular conjugates, such as antibody-drug conjugates (ADCs) and PROTACs, leveraging its reactive epoxide and protected amine functionalities.
• Polymer Modification: Serves as a cross-linking agent or functional monomer for creating specialty polymers with tailored properties for medical or industrial applications.
• Peptidomimetic Synthesis: Integral in constructing piperazine-containing scaffolds that mimic peptide structures for enhanced stability and bioavailability.
• Chemical Biology Probes: Employed in the development of probes and tools for studying biological pathways and target engagement.
• Agrochemical Research: Intermediate in the development of new crop protection agents and pesticides.

Basic Information

Product Name	1-(2,3-Epoxypropyl)-4-tert-Butoxycarbonylpiperazine
CAS No.	159873-06-0
Molecular Formula	C12H22N2O3
Molecular Weight	242.32 g/mol
Synonyms	4-Boc-1-(2,3-epoxypropyl)piperazine; 1-(Oxiran-2-ylmethyl)-4-(tert-butoxycarbonyl)piperazine; N-Boc-N'-(2,3-epoxypropyl)piperazine; tert-Butyl 4-(2,3-epoxypropyl)piperazine-1-carboxylate; 1-Glycidyl-4-(N-Boc)piperazine; 4-(tert-Butoxycarbonyl)-1-(2,3-epoxypropyl)piperazine; 1-(2,3-Epoxypropyl)piperazine-4-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 1-(2,3-Epoxypropyl)-4-tert-Butoxycarbonylpiperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, identity, and consistency, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity (typically by HPLC), identity (IR, NMR), and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.