Description

1-Pyrrolidineacetaldehyde, 2-Formyl-3-Hydroxy-, (2R-Cis)- (9Ci) is a chiral, multifunctional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique stereochemistry and reactive aldehyde and hydroxyl groups, enabling the construction of complex molecular architectures with high precision. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in classes requiring pyrrolidine-based scaffolds.
• Asymmetric Synthesis: Utilized as a precursor or catalyst ligand in stereoselective reactions to produce enantiomerically pure compounds.
• Agrochemical Research: Serves as a building block for novel herbicides, fungicides, and plant growth regulators requiring specific stereochemistry.
• Fine Chemical Production: Employed in the custom synthesis of specialty chemicals, flavors, and fragrances where structural complexity is needed.
• Academic & R&D: Used in university and institutional laboratories for methodological studies in organic chemistry and catalysis.
• Material Science Precursor: Potential application in synthesizing novel ligands for metal-organic frameworks (MOFs) or functional polymers.

Basic Information

Item	Detail
Product Name	1-Pyrrolidineacetaldehyde, 2-Formyl-3-Hydroxy-, (2R-Cis)- (9Ci)
CAS No.	159561-66-7
Molecular Formula	C7H11NO3
Molecular Weight	157.17 g/mol
Synonyms	(2R,3S)-2-Formyl-3-hydroxypyrrolidine-1-acetaldehyde; (2R-Cis)-2-Formyl-3-hydroxy-1-pyrrolidineacetaldehyde; 1-Pyrrolidineacetaldehyde, 2-formyl-3-hydroxy-, (2R-cis)-; (2R,3S)-3-Hydroxy-2-formyl-1-pyrrolidineacetaldehyde; L-threo-2-Formyl-3-hydroxypyrrolidine-1-acetaldehyde; A chiral hydroxyformyl pyrrolidine derivative
EINECS	Contact for details

Quality Control

Every batch of 1-Pyrrolidineacetaldehyde, 2-Formyl-3-Hydroxy-, (2R-Cis)- (9Ci) is produced and tested under strict quality management protocols to ensure identity, purity, and consistency. We provide comprehensive analytical data including HPLC purity, chiral purity (enantiomeric excess), and spectroscopic confirmation (NMR, IR). A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting compliance with agreed specifications. Our quality system supports development from research quantities to commercial scale under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.