Description

1,3,2-Dioxaborolane,2-(3,3-Diethoxy-1-Propyn-1-Yl)-4,4,5,5-Tetramethyl- is a specialized organoboron reagent, specifically a protected acetylene-containing boronic ester, with the CAS number 159087-48-6. This compound is a critical building block in modern synthetic chemistry, enabling the precise construction of complex molecular architectures through cross-coupling and other advanced transformations. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, reliable intermediates for drug discovery, ligand synthesis, and polymer development.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for introducing alkynyl-substituted aryl or heteroaryl groups into target molecules, crucial for pharmaceutical and agrochemical synthesis.
• Pharmaceutical Intermediate: Serves as a versatile building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring complex alkynyl motifs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where specific alkynyl-boronate functionality is required.
• Material Science & Polymer Chemistry: Employed in the synthesis of conjugated polymers, organic semiconductors, and advanced materials with tailored electronic properties.
• Ligand and Catalyst Development: A precursor for creating specialized phosphine or N-heterocyclic carbene (NHC) ligands containing alkynyl groups for catalysis.
• Chemical Biology & Bioconjugation: Useful for synthesizing probes and linkers for bioorthogonal chemistry and protein labeling applications.

Basic Information

Item	Details
Product Name	1,3,2-Dioxaborolane,2-(3,3-Diethoxy-1-Propyn-1-Yl)-4,4,5,5-Tetramethyl-
CAS No.	159087-48-6
Molecular Formula	C13H23BO4
Molecular Weight	254.13 g/mol
Synonyms	2-(3,3-Diethoxyprop-1-yn-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-(3,3-diethoxy-1-propynyl)-1,3,2-dioxaborolane; (3,3-Diethoxyprop-1-yn-1-yl)boronic acid pinacol ester; 3,3-Diethoxy-1-propynylboronic acid pinacol ester; Pinacol (3,3-diethoxyprop-1-yn-1-yl)boronate; 1-Propynylboronic acid, 3,3-diethoxy-, pinacol ester; Alkynyl boronic ester CAS 159087-48-6.
EINECS	Contact for details

Quality Control

Our 1,3,2-Dioxaborolane,2-(3,3-Diethoxy-1-Propyn-1-Yl)-4,4,5,5-Tetramethyl- is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including NMR (¹H, ¹³C, ¹¹B), HPLC for purity assessment, and GC for residual solvent analysis to ensure it meets the high standards required for research and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (argon or nitrogen) and at temperatures between 2°C and 8°C for long-term stability. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.