Description

4,4,5,5-Tetramethyl-2-(Phenylethynyl)-1,3,2-Dioxaborolane is a high-value organoboron building block, specifically a pinacol boronic ester derivative, with CAS number 159087-45-3. This compound is a critical reagent in modern synthetic chemistry, enabling the efficient construction of complex molecular architectures through cross-coupling reactions. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing carbon-carbon bonds with high precision and yield.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for the palladium-catalyzed coupling with aryl or vinyl halides to form biaryl or styrenyl structures, a cornerstone reaction in pharmaceutical synthesis.
• Pharmaceutical Intermediate Synthesis: Used in the research and production of active pharmaceutical ingredients (APIs), particularly for creating complex, sterically hindered biaryl motifs common in modern drug candidates.
• Agrochemical Product Development: Employed in the synthesis of novel herbicides, fungicides, and insecticides that require specific aromatic ring systems.
• Material Science & Organic Electronics: Serves as a precursor for synthesizing conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and semiconductors.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and tags for imaging and diagnostic applications due to its robust reactivity and stability.
• Academic & Industrial Research: A fundamental tool in methodological development and discovery chemistry within university and corporate R&D laboratories.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(Phenylethynyl)-1,3,2-Dioxaborolane
CAS No.	159087-45-3
Molecular Formula	C14H17BO2
Molecular Weight	228.10 g/mol
Synonyms	2-(Phenylethynyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (Phenylethynyl)pinacolborane; Ethynylphenylboronic acid pinacol ester; Pinacol (phenylethynyl)boronate; Phenylethynylboronic acid pinacol ester; 1,3,2-Dioxaborolane, 2-(2-phenylethynyl)-4,4,5,5-tetramethyl-; B-(Phenylethynyl)pinacol boronate
EINECS	Contact for details

Quality Control

Our 4,4,5,5-Tetramethyl-2-(Phenylethynyl)-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including NMR, HPLC, and GC analysis, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our production adheres to cGMP guidelines where applicable, ensuring consistency and reliability for critical research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal reactivity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.