Description

Escin Iia is a high-purity, standardized triterpenoid saponin compound, a key active constituent derived from the horse chestnut seed (*Aesculus hippocastanum* L.). Its precise chemical profile makes it a critical reference standard and active ingredient for advanced pharmaceutical and nutraceutical research and development. This compound is essential for manufacturers and R&D laboratories focused on developing venotonic, anti-inflammatory, and vascular protective formulations. The product is supplied as Escin Iia CAS NO 158732-55-9, ensuring traceability and quality for demanding applications.

Application

• Pharmaceutical Reference Standard: Used as a primary chemical reference material (CRM) for the quality control and assay of horse chestnut extracts and finished drug products in pharmacopoeial methods (e.g., USP, EP).
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key building block in the synthesis and standardization of complex botanical drug substances targeting chronic venous insufficiency (CVI) and related vascular disorders.
• Nutraceutical & Cosmetic Actives: Incorporated into high-end dietary supplements and topical formulations (e.g., creams, gels) for its clinically studied benefits in reducing edema, inflammation, and improving microcirculation.
• Biomedical Research: A vital tool for in-vitro and in-vivo studies investigating mechanisms of action related to capillary permeability, anti-exudative effects, and inflammatory pathways.
• Analytical Chemistry: Employed as a calibration standard in HPLC, UPLC, and LC-MS methods for the quantitative analysis of Escin mixtures and botanical extracts.

Basic Information

Product Name	Escin Iia
CAS No.	158732-55-9
Molecular Formula	C55H86O24
Molecular Weight	1131.26 g/mol
Synonyms	Aescin IIa; β-Aescin; Escin IIa; Aesculus saponin I; Escin (main component); 21β-Angeloylprotoaescigenin-3β-[2-O-(4-methoxycinnamoyl)]-β-D-glucopyranosiduronic acid; Horse Chestnut Saponin Aescin IIa
EINECS	Contact for details

Quality Control

Every batch of Escin Iia is manufactured and controlled under a strict quality management system. The product undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to meet exacting standards for reference materials and API intermediates. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results for assay, related substances, and residual solvents. We support compliance with cGMP, ICH Q7, and relevant pharmacopoeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under conditions that minimize exposure to ambient light and humidity to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤2.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.