Description

3-Chloro-4-(Trifluoromethoxy)Benzoic Acid is a high-value fluorinated aromatic building block essential for advanced chemical synthesis. Its unique structure, featuring both chloro and trifluoromethoxy substituents, makes it a critical intermediate for developing compounds with enhanced biological activity and material properties. This product is primarily needed by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate sophisticated fluorinated motifs into their target molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of new drugs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group can improve lipophilicity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, contributing to improved performance and stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Reagent: A versatile reagent in cross-coupling reactions and carboxylate transformations for constructing complex organic architectures in academic and industrial research.

Basic Information

Product Name	3-Chloro-4-(Trifluoromethoxy)Benzoic Acid
CAS No.	158580-93-9
Molecular Formula	C8H4ClF3O3
Molecular Weight	240.56 g/mol
Synonyms	3-Chloro-4-(trifluoromethoxy)benzoic acid; Benzoic acid, 3-chloro-4-(trifluoromethoxy)-; 4-Trifluoromethoxy-3-chlorobenzoic acid; 3-Chloro-4-trifluoromethoxybenzoic acid; 158580-93-9; 3-Chloro-α,α,α-trifluoro-p-anisic acid; 3-Chloro-4-(trifluoromethoxy)benzenecarboxylic acid
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-(Trifluoromethoxy)Benzoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP, ISO, and other relevant regulatory frameworks for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids, organic solvents, fluorides, and strong alkalis. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.