Description

4-Bromo-2-Chloro-1-(Trifluoromethoxy)Benzene is a high-purity halogenated benzene derivative that serves as a critical building block in advanced organic synthesis. Its unique trifluoromethoxy and halogen substituents make it a valuable intermediate for creating complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in medicinal chemistry programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated aromatic compounds for electronic materials, including liquid crystal displays and organic light-emitting diodes.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) due to the presence of both bromo and chloro leaving groups, allowing for sequential functionalization.
• Fluorine Chemistry Research: A valuable reagent for studying the influence of the trifluoromethoxy group on aromatic systems in academic and industrial R&D settings.
• Specialty Polymer Modifier: Incorporated as a monomer or additive to impart specific properties like chemical resistance or altered refractive index to high-performance polymers.

Basic Information

Product Name	4-Bromo-2-Chloro-1-(Trifluoromethoxy)Benzene
CAS No.	158579-80-7
Molecular Formula	C7H3BrClF3O
Molecular Weight	275.45 g/mol
Synonyms	1-Bromo-4-chloro-2-(trifluoromethoxy)benzene; 2-Chloro-4-bromo-1-(trifluoromethoxy)benzene; 4-Bromo-2-chloro-α,α,α-trifluoroanisole; 4-Bromo-2-chloro-1-(trifluoromethoxy)benzene; 4-Bromo-2-chloro-(trifluoromethoxy)benzene; Benzene, 4-bromo-2-chloro-1-(trifluoromethoxy)-; 2-Chloro-4-bromo-α,α,α-trifluoroanisole
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is analyzed using advanced techniques including GC, HPLC, NMR, and MS to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) are available upon request, providing full transparency and traceability for your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥98.0% (Typical 99.0%)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.