Description

2,3-Difluorophenyl Chlorothioformate is a specialized organosulfur reagent featuring a chlorothioformate group on a difluorinated aromatic ring. This compound matters as a versatile and reactive building block for introducing the 2,3-difluorophenylthio moiety into target molecules, enabling the synthesis of complex chemical architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those requiring a fluorinated arylthio group for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the difluorophenyl group contributes to efficacy and selectivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of monomers and polymers with specific electronic or surface properties.
• Custom Chemical Synthesis: A critical reagent for contract research and manufacturing organizations (CROs/CMOs) producing bespoke fine chemicals for clients.
• Fluorine Chemistry Studies: Used as a model compound in research exploring the effects of ortho- and meta-fluorine substitution on reaction pathways.

Basic Information

Product Name	2,3-Difluorophenyl Chlorothioformate
CAS No.	158178-41-7
Molecular Formula	C7H3ClF2OS
Molecular Weight	208.61 g/mol
Synonyms	2,3-Difluorophenyl chloromethanethioate; Carbonochloridothioic acid, O-(2,3-difluorophenyl) ester; Chlorothioformic acid O-(2,3-difluorophenyl) ester; 2,3-Difluorophenyl chlorothionoformate; O-(2,3-Difluorophenyl) chlorothioformate
EINECS	Contact for details

Quality Control

Our 2,3-Difluorophenyl Chlorothioformate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, oxidizing agents, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.