Description

(E)-2-(3,3-Dimethylbut-1-En-1-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane CAS NO 157945-83-0 is a high-purity, advanced pharmaceutical intermediate belonging to the class of pinacol boronic esters. This compound is a critical building block in modern synthetic organic chemistry, enabling the formation of carbon-carbon bonds through Suzuki-Miyaura cross-coupling reactions. It is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality reagents for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for small molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile organoboron reagent for palladium-catalyzed cross-coupling to form biaryl and other carbon-carbon bonds with high efficiency and selectivity.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides.
• Material Science Research: Employed in the development of organic electronic materials, such as polymers for OLEDs and organic photovoltaics.
• Chemical Biology & Proteomics: Utilized as a tool compound for bioconjugation and the development of chemical probes.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis services catering to R&D and pilot-scale production.

Basic Information

Product Name	(E)-2-(3,3-Dimethylbut-1-En-1-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	157945-83-0
Molecular Formula	C₁₄H₂₇BO₂
Molecular Weight	238.18 g/mol
Synonyms	(E)-3,3-Dimethyl-1-buten-1-ylboronic acid pinacol ester; (E)-2-(3,3-Dimethylbut-1-enyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; trans-2-(3,3-Dimethyl-1-butenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (E)-1-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,3-dimethylbut-1-ene; Pinacol (E)-3,3-dimethyl-1-butenylboronate; (E)-3,3-Dimethyl-1-butenylboronic Acid Pinacol Ester; 157945-83-0
EINECS	Contact for details

Quality Control

Our (E)-2-(3,3-Dimethylbut-1-En-1-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹¹B), HPLC, and GC analysis, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with full analytical data are provided and available upon request, supporting compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.