Description

Taxuspine B is a highly specific diterpenoid alkaloid isolated from the yew tree (genus *Taxus*), known for its complex and bioactive chemical structure. This compound serves as a critical reference standard and advanced intermediate in pharmaceutical research and development, particularly for studying structure-activity relationships and metabolic pathways. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical synthesis sectors who require high-purity, well-characterized natural product derivatives for drug discovery programs.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of yew-derived compounds in drug development and quality control laboratories.
• Biochemical Research: Serves as a key reagent in studies investigating the biosynthesis, biological activity, and mechanism of action of taxane-related alkaloids.
• Organic Synthesis Intermediate: Acts as a sophisticated building block for the semi-synthesis of novel chemical entities and analogs for biological screening.
• Analytical Method Development: Employed to develop and validate chromatographic methods (e.g., HPLC, LC-MS) for the detection and quantification of related natural products.
• Academic & Institutional Research: Utilized in universities and research institutes for pharmacological studies and natural product chemistry education.

Basic Information

Item	Detail
Product Name	Taxuspine B
CAS No.	157414-05-6
Molecular Formula	C27H35NO8
Molecular Weight	501.57 g/mol
Synonyms	Taxuspine B; (1S,2S,3R,4S,5R,7S,8S,10S,13S)-4,10-Diacetoxy-2-benzoyloxy-9-oxo-5,20-epoxy-1,13-dihydroxy-7-(2-methylbutanoyloxy)tax-11-en-13-yl acetate; 5,20-Epoxy-1,2,4,7,10,13-hexahydroxy-9-oxotax-11-ene-2,4,10,13-tetraacetate 7-(2-methylbutanoate) 2-benzoate; NSC 654074; A related taxane alkaloid.
EINECS	Contact for details

Quality Control

Our Taxuspine B is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and MS. We support research and development with materials that meet the stringent requirements for pharmaceutical reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.