Description

(R)-α-[2-(1-Naphthalenyloxy)Ethyl]-Benzenemethanol CAS NO 156453-53-1 is a chiral benzhydrol derivative characterized by its naphthalene and phenyl ether structure, serving as a valuable non-racemic synthetic intermediate. This compound matters for its role in enabling the stereoselective synthesis of complex molecules, where the (R)-configuration is critical for biological activity or material properties. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers developing active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials that require precise chiral control.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of potential drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of chiral pesticides and herbicides where specific stereochemistry enhances efficacy and reduces environmental impact.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands used in asymmetric catalysis, such as in hydrogenation or cross-coupling reactions.
• Material Science Research: Employed in the development of chiral liquid crystals or organic semiconductors for advanced electronic applications.
• Academic & Industrial R&D: A versatile tool for methodological studies in organic chemistry focused on etherification, chiral resolution, and benzylic chemistry.

Basic Information

Product Name	(R)-α-[2-(1-Naphthalenyloxy)Ethyl]-Benzenemethanol
CAS No.	156453-53-1
Molecular Formula	C19H18O2
Molecular Weight	278.35 g/mol
Synonyms	(R)-1-(2-(Naphthalen-1-yloxy)ethyl)-1-phenylmethanol; (R)-α-[2-(1-Naphthyloxy)ethyl]benzyl Alcohol; (R)-1-Phenyl-1-[2-(1-naphthyloxy)ethyl]methanol; (R)-2-(1-Naphthalenyloxy)-1-phenylethanol; (R)-Benzenemethanol, α-[2-(1-naphthalenyloxy)ethyl]-; (R)-1-(2-(Naphthalen-1-yloxy)ethyl)-1-phenylethanol (common misnomer); AR-NEPhM (abbreviation); (R)-Naphthyloxyethylphenylmethanol
EINECS	Contact for details

Quality Control

Our production of (R)-α-[2-(1-Naphthalenyloxy)Ethyl]-Benzenemethanol adheres to strict quality management protocols, ensuring high chiral purity and chemical integrity for critical R&D and scale-up processes. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing chiral purity (enantiomeric excess), chemical purity, and identity confirmation. We maintain compliance with relevant ICH guidelines and can support development under cGMP standards for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed to minimize contact with air and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.