Description

4-(4-(Trifluoromethyl)Phenyl)-2-Methylbut-3-Yn-2-Ol is a specialized organic compound featuring a trifluoromethylphenyl group and a tertiary propargylic alcohol moiety. This unique structure makes it a valuable advanced pharmaceutical intermediate and a versatile building block in synthetic organic chemistry. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the synthesis of complex molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the trifluoromethyl group for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the CF3 group is a critical pharmacophore.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced materials with specific optical or electronic properties.
• Ligand and Catalyst Development: Employed in organometallic chemistry for creating novel ligands and catalysts used in asymmetric synthesis and cross-coupling reactions.
• Fluorine Chemistry Research: An essential reagent for studying the introduction and effects of fluorine atoms in organic molecules within academic and industrial R&D settings.
• Fine Chemical Production: Intermediate in the multi-step synthesis of complex fine chemicals and specialty compounds for various high-value industrial applications.

Basic Information

Product Name	4-(4-(Trifluoromethyl)Phenyl)-2-Methylbut-3-Yn-2-Ol
CAS No.	156301-63-2
Molecular Formula	C12H11F3O
Molecular Weight	228.21 g/mol
Synonyms	2-Methyl-4-[4-(trifluoromethyl)phenyl]-3-butyn-2-ol; 4-(4-Trifluoromethylphenyl)-2-methyl-3-butyn-2-ol; 2-Methyl-4-(α,α,α-trifluoro-p-tolyl)-3-butyn-2-ol; 3-Butyn-2-ol, 2-methyl-4-[4-(trifluoromethyl)phenyl]-; 2-Methyl-4-(4-trifluoromethylphenyl)but-3-yn-2-ol; 4-(4-Trifluoromethylphenyl)-2-methylbut-3-yn-2-ol; α,α,α-Trifluoro-2-methyl-4-(4-methylphenyl)-3-butyn-2-ol (common misnomer variant).
EINECS	Contact for details

Quality Control

Our production of 4-(4-(Trifluoromethyl)Phenyl)-2-Methylbut-3-Yn-2-Ol adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for critical R&D and scale-up processes. Quality is verified through comprehensive analytical testing including HPLC, GC, NMR, and IR spectroscopy. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support compliance with REACH and other global regulatory frameworks as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. The compound may be moisture-sensitive; containers should be kept tightly sealed when not in use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Standard Grade)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.