Description

Methyl (p-Fluorobenzoyl)Formate CAS NO 156276-23-2 is a high-purity fluorinated aromatic ester, serving as a versatile and critical building block in advanced organic synthesis. Its value lies in the strategic incorporation of both a reactive ester group and a fluorine atom, enabling precise molecular modifications. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated aromatic rings to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of modern herbicides, fungicides, and insecticides where the fluorine atom improves biological activity and environmental persistence.
• Material Science Research: Employed in the creation of specialty polymers, liquid crystals, and advanced organic electronic materials that benefit from fluorinated components.
• Cross-Coupling Reactions: Acts as an effective electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for constructing biaryl systems.
• Fluorine Chemistry Studies: Serves as a standard substrate for investigating new fluorination methodologies and the effects of fluorine substitution on chemical reactivity.
• Peptide Mimetic & Prodrug Development: The ester functionality makes it useful for constructing peptide analogs or as a prodrug linker in medicinal chemistry programs.

Basic Information

Product Name	Methyl (p-Fluorobenzoyl)Formate
CAS No.	156276-23-2
Molecular Formula	C9H7FO3
Molecular Weight	182.15 g/mol
Synonyms	Methyl 4-fluorobenzoylformate; Methyl 4-fluorobenzoylformate; Methyl (4-fluorobenzoyl)formate; p-Fluorobenzoylformic Acid Methyl Ester; 4-Fluorobenzoylformic Acid Methyl Ester; Methyl α-oxo-4-fluorobenzeneacetate; Methyl 2-oxo-2-(4-fluorophenyl)acetate; Methyl 4-fluorophenylglyoxylate
EINECS	Contact for details

Quality Control

Our production of Methyl (p-Fluorobenzoyl)Formate adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment, supporting compliance with cGMP and ICH guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.