Description

Manumycin E CAS NO 156250-43-0 is a potent and specific natural product inhibitor of farnesyltransferase, an enzyme critical in the Ras signaling pathway. This compound is a vital research tool for studying oncogenic processes, cellular proliferation, and signal transduction mechanisms. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on cancer biology and drug discovery.

Application

• Biochemical Research: Used as a selective inhibitor to study the role of farnesyltransferase and Ras protein function in cell signaling pathways.
• Oncology Research: A key tool for investigating potential therapeutic targets in various cancers driven by Ras mutations.
• Mechanistic Studies: Employed in vitro and in cell-based assays to elucidate the mechanisms of cell growth, differentiation, and apoptosis.
• Drug Discovery Screening: Serves as a reference compound or positive control in high-throughput screening for novel anti-cancer agents.
• Academic Laboratories: Fundamental research in molecular biology and biochemistry to understand protein prenylation.

Basic Information

Product Name	Manumycin E
CAS No.	156250-43-0
Molecular Formula	C31H38N2O6
Molecular Weight	534.65 g/mol
Synonyms	Manumycin E; Antibiotic UCF 116-C; UCF 116-C; Farnesyltransferase inhibitor Manumycin E; (2E,4E,6E,8E)-10-[(2S,3S)-3-[(2S)-butan-2-yl]oxiran-2-yl]-2,4,6,8-decatetraenoic acid (2E,4E)-5-methyl-6-phenylhexa-2,4-dienamide; L 156250-43-0
EINECS	Contact for details

Quality Control

Our Manumycin E is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, purity, and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, desiccate to maintain stability. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.