Description

3,5-Difluoro-4-(trifluoromethyl)bromobenzene is a high-value, multi-fluorinated aromatic building block essential for advanced chemical synthesis. Its unique structure, featuring both bromine and fluorine substituents, makes it a critical intermediate for introducing specific fluorinated motifs into target molecules. This compound is primarily sought after by R&D and production chemists in the pharmaceutical and agrochemical industries for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of fluorine-containing drugs where its structure can influence bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, leveraging the fluorine atoms to enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for creating fluorinated aromatic cores used in electronic display technologies and organic light-emitting diodes.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Stille) to form complex biaryl structures.
• Fluorinated Polymer Research: Acts as a monomer or modifier in the research and development of specialty polymers with enhanced chemical resistance and thermal stability.
• Material Science Research: Employed in the synthesis of novel fluorinated ligands for catalysis and advanced organic frameworks.

Basic Information

Product Name	3,5-Difluoro-4-(Trifluoromethyl)Bromobenzene
CAS No.	156243-64-0
Molecular Formula	C7H2BrF5
Molecular Weight	260.99 g/mol
Synonyms	1-Bromo-3,5-difluoro-4-(trifluoromethyl)benzene; 4-Bromo-2,6-difluorobenzotrifluoride; 2,6-Difluoro-4-(trifluoromethyl)bromobenzene; 3,5-Difluoro-α,α,α-trifluoro-4-bromotoluene; Benzene, 1-bromo-3,5-difluoro-4-(trifluoromethyl)-; 156243-64-0; 4-Bromo-2,6-difluoro-α,α,α-trifluorotoluene
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for all our fluorinated intermediates. Each batch of 3,5-Difluoro-4-(Trifluoromethyl)Bromobenzene is analyzed using advanced chromatographic and spectroscopic techniques to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. Our quality system is designed to meet the exacting standards of cGMP and ISO guidelines for fine chemical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.