Description

δ5(10),6,8(9)-D-(-)-Norgestrel is a high-purity, synthetic progestin steroid intermediate. This compound is of significant value in the pharmaceutical industry for the research and development of active pharmaceutical ingredients (APIs) and advanced steroid-based therapeutics. It is primarily required by manufacturers and R&D laboratories specializing in hormonal contraceptives, hormone replacement therapies, and other steroidal drug synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of progestogen-based Active Pharmaceutical Ingredients (APIs).
• Hormonal Contraceptive Development: Used in the research and production of next-generation oral contraceptives and long-acting reversible contraceptives (LARCs).
• Hormone Replacement Therapy (HRT): Serves as a critical precursor in formulations for managing menopausal symptoms and hormonal deficiencies.
• Steroid Research: Employed in academic and industrial laboratories for studying steroid receptor activity and metabolic pathways.
• Process Chemistry & Scale-Up: Utilized in process development and optimization for the commercial manufacturing of steroidal drugs.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and regulatory testing.

Basic Information

Product Name	δ5(10),6,8(9)-D-(-)-Norgestrel
CAS No.	155683-59-3
Molecular Formula	C₂₁H₂₈O₂
Molecular Weight	312.45 g/mol
Synonyms	13-Ethyl-17-hydroxy-18,19-dinor-17α-pregna-4,9,11-trien-20-yn-3-one; D-(-)-13β-Ethyl-17α-ethynyl-17β-hydroxygon-4,9,11-triene-3-one; Levonorgestrel Impurity; Norgestrel Intermediate; 17α-Ethynyl-13β-ethyl-17β-hydroxy-4,9,11-gonatriene-3-one; δ5(10),6,8(9)-Norgestrel
EINECS	Contact for details

Quality Control

Our δ5(10),6,8(9)-D-(-)-Norgestrel is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) documenting full specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.