Description

3H-Diazirine,3-Bromo-3-(1-Methylethyl)-(9Ci) is a specialized diazirine derivative, a class of compounds renowned for their utility as photoaffinity labeling reagents and carbene precursors in advanced chemical synthesis. This compound is valued for its ability to generate highly reactive carbene intermediates upon photolysis, enabling the study of biological interactions and the construction of complex molecular architectures. It is primarily sought by researchers and process development chemists in the pharmaceutical, agrochemical, and materials science industries for applications in photochemistry, bioconjugation, and polymer cross-linking.

Application

• Photoaffinity Labeling (PAL): A critical tool in chemical biology and drug discovery for covalently capturing and identifying transient protein-ligand interactions or mapping binding sites.
• Carbene Chemistry: Serves as a precursor for generating reactive carbene species used in C-H insertion, cyclopropanation, and other bond-forming reactions under mild, light-induced conditions.
• Bioconjugation and Probe Development: Used to create photoactivatable cross-linkers for attaching reporter molecules (e.g., fluorophores, biotin) to biomolecules like proteins, peptides, or nucleic acids.
• Polymer and Materials Science: Employed in the surface modification of polymers and the photo-initiated cross-linking of materials to alter physical properties such as adhesion, wettability, or mechanical strength.
• Organic Synthesis Intermediate: Functions as a building block for synthesizing more complex heterocyclic compounds or molecules with isopropyl-bromodiazirine functional groups.
• Proteomics Research: Integral to strategies for identifying and characterizing protein-protein interactions and protein complexes within living cells.

Basic Information

Product Name	3H-Diazirine,3-Bromo-3-(1-Methylethyl)-(9Ci)
CAS No.	155052-13-4
Molecular Formula	C5H9BrN2
Molecular Weight	177.04 g/mol
Synonyms	3-Bromo-3-isopropyldiazirine; 3-Isopropyl-3-bromodiazirine; 3-(Bromoisopropyl)diazirine; Diaziridine, 3-bromo-3-(1-methylethyl)-; 3-(1-Methylethyl)-3-bromo-3H-diazirine; 3-Bromo-3-(propan-2-yl)diazirine; Photoactivatable isopropyl bromodiazirine
EINECS	Contact for details

Quality Control

Every batch of 3H-Diazirine,3-Bromo-3-(1-Methylethyl)-(9Ci) is manufactured and tested under strict quality management protocols to ensure consistency and reliability for research applications. Our standard analytical control includes identity confirmation by spectroscopic methods and purity assessment by chromatography. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment. We support custom synthesis and can tailor purity specifications to meet the stringent requirements of advanced R&D projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its light-sensitive nature, handling and aliquoting should be performed under subdued light or using amber glassware to maintain stability. For long-term storage, consider keeping the container under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.