Description

Z-D-Cha-Oh is a protected amino acid derivative, specifically the Z-protected form of D-cyclohexylalanine. This high-purity chiral building block is essential for the controlled synthesis of complex peptides and peptidomimetics, offering researchers and manufacturers precise stereochemical control. It is a critical intermediate for pharmaceutical R&D, particularly in developing therapeutic peptides, protease inhibitors, and other bioactive compounds. Professionals in pharmaceutical development, biotechnology, and advanced organic synthesis rely on this reagent for its consistent quality and reliable performance in sensitive synthetic pathways.

Application

• Pharmaceutical Intermediate: Key building block for the solid-phase and solution-phase synthesis of therapeutic peptides and peptidomimetics.
• Protease Inhibitor Development: Used in research and production of inhibitors targeting specific enzymes like HCV protease.
• Chiral Synthesis: Serves as a source of enantiomerically pure D-cyclohexylalanine for asymmetric synthesis and molecular design.
• Bioconjugation & Labeling: Employed in the preparation of peptide-based conjugates for diagnostic and targeted drug delivery applications.
• Academic & Industrial R&D: A standard reagent in medicinal chemistry labs for exploring structure-activity relationships (SAR) and novel bioactive entities.
• Custom Peptide Services: Supplied to CROs and CDMOs for the manufacture of custom peptide sequences for clients.

Basic Information

Item	Details
Product Name	Z-D-Cha-Oh
CAS No.	154802-74-1
Molecular Formula	C₁₇H₂₃NO₄
Molecular Weight	305.37 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]-D-cyclohexylalanine; Z-D-Cyclohexylalanine; (R)-2-(((Benzyloxy)carbonyl)amino)-3-cyclohexylpropanoic acid; D-Cyclohexylalanine Z-derivative; N-Cbz-D-cyclohexylalanine; Z-D-Cha; Boc-D-Cha-OH (Note: Boc is a different protecting group); Fmoc-D-Cha-OH (Note: Fmoc is a different protecting group)
EINECS	Contact for details

Quality Control

Every batch of Z-D-Cha-Oh is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with high-purity standards typical for advanced pharmaceutical intermediates. A detailed Certificate of Analysis (COA) is provided with each shipment, reporting key parameters such as chiral purity, chemical purity, and identity confirmation. Our quality commitment supports your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.