Description

2(3H)-Furanone,5-Ethoxydihydro-4-Methyl-4-(Trifluoromethyl)-,cis-(9Ci) is a specialized fluorinated furanone derivative, a high-value intermediate prized for its unique stereochemistry and trifluoromethyl group. This compound matters for its role in enabling the synthesis of complex molecules with enhanced metabolic stability and bioavailability. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries, where it serves as a critical building block for novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group can improve lipophilicity and biological activity.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers and advanced materials with specific optical or electronic properties.
• Chemical Biology Probes: Serves as a scaffold for creating molecular probes to study enzyme mechanisms and biological pathways.
• Flavor & Fragrance Chemistry: Potential intermediate for synthesizing novel lactone-based aroma compounds, though specific applications require development.

Basic Information

Product Name	2(3H)-Furanone,5-Ethoxydihydro-4-Methyl-4-(Trifluoromethyl)-,cis-(9Ci)
CAS No.	154389-75-0
Molecular Formula	C8H11F3O3
Molecular Weight	212.17 g/mol
Synonyms	cis-5-Ethoxy-4-methyl-4-(trifluoromethyl)dihydrofuran-2(3H)-one; 4-Methyl-4-(trifluoromethyl)-5-ethoxydihydro-2(3H)-furanone, cis-; 5-Ethoxy-4-methyl-4-(trifluoromethyl)tetrahydro-2-furanone; (4R,5S)-5-Ethoxy-4-methyl-4-(trifluoromethyl)dihydrofuran-2(3H)-one (if stereochemistry is specified); Dihydro-5-ethoxy-4-methyl-4-(trifluoromethyl)-2(3H)-furanone, cis-; 154389-75-0; FC-254 (potential internal code).
EINECS	Contact for details

Quality Control

Every batch of our 2(3H)-Furanone,5-Ethoxydihydro-4-Methyl-4-(Trifluoromethyl)-,cis-(9Ci) undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as chiral purity, chemical purity (by GC/HPLC), and residual solvent content. Our quality system is designed to support cGMP and ISO standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de (cis-isomer)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.