Description

3-(Dimethylamino)-1-[3-(Trifluoromethoxy)-Phenyl]Prop-2-En-1-One is a specialized organic building block featuring a trifluoromethoxy-substituted aromatic ketone core with a dimethylamino enone side chain. This compound is valued for its unique molecular architecture, which combines electron-donating and electron-withdrawing groups, making it a versatile intermediate in advanced synthesis. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, particularly in the development of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders or requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of new herbicides, fungicides, or insecticides, where the trifluoromethoxy group can improve lipophilicity and biological activity.
• Material Science Precursor: Serves as a building block for advanced organic materials, such as liquid crystals, organic semiconductors, or polymers with specific optical or electronic properties.
• Chemical Synthesis: Employed in organic reactions like Michael additions or cyclizations to create complex heterocyclic compounds for various research applications.
• Fluorine Chemistry Studies: Acts as a model compound in academic and industrial research focused on the synthesis and reactivity of fluorinated aromatic systems.

Basic Information

Product Name	3-(Dimethylamino)-1-[3-(Trifluoromethoxy)-Phenyl]Prop-2-En-1-One
CAS No.	154258-46-5
Molecular Formula	C₁₂H₁₂F₃NO₂
Molecular Weight	259.23 g/mol
Synonyms	1-[3-(Trifluoromethoxy)phenyl]-3-(dimethylamino)-2-propen-1-one; 3-(Dimethylamino)-1-[3-(trifluoromethoxy)phenyl]-2-propen-1-one; 3-(Dimethylamino)-1-(3-trifluoromethoxyphenyl)prop-2-en-1-one; (E)-3-(Dimethylamino)-1-(3-(trifluoromethoxy)phenyl)prop-2-en-1-one; 3-Dimethylamino-1-(3-trifluoromethoxyphenyl)propenone; Enaminone derivative CAS 154258-46-5; Trifluoromethoxy chalcone derivative
EINECS	Contact for details

Quality Control

Our production of 3-(Dimethylamino)-1-[3-(Trifluoromethoxy)-Phenyl]Prop-2-En-1-One adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all test results are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and fluorides. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.