Description

Chloroacetyl-1,2,3,4-Tetramethylbenzene CAS NO 153275-53-7 is a specialized aromatic ketone derivative, serving as a high-value synthetic intermediate in advanced organic synthesis. Its core value lies in providing a reactive chloroacetyl handle on a sterically hindered, electron-rich tetramethylbenzene core, enabling precise molecular construction. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries who require sophisticated building blocks for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those requiring complex, multi-substituted aromatic systems.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and pesticides where the tetramethylbenzene moiety imparts specific biological activity.
• Material Science Research: Serves as a precursor for organic semiconductors, liquid crystals, or photoactive materials due to its tailored electronic properties.
• Chemical Biology & Proteomics: Can be utilized as a scaffold or linker in the development of chemical probes, affinity labels, or bioconjugation reagents.
• Catalyst & Ligand Development: Acts as a starting material for synthesizing specialized ligands for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A critical intermediate for custom synthesis houses serving the fine chemical and life science industries.

Basic Information

Product Name	Chloroacetyl-1,2,3,4-Tetramethylbenzene
CAS No.	153275-53-7
Molecular Formula	C14H17ClO
Molecular Weight	236.74 g/mol
Synonyms	1-(Chloroacetyl)-1,2,3,4-tetramethylbenzene; 2,3,5,6-Tetramethyl-α-chloroacetophenone; α-Chloro-2,3,5,6-tetramethylacetophenone; Chloroacetylpentamethylbenzene (common name); 1-Chloro-2-oxo-2-(2,3,5,6-tetramethylphenyl)ethane; 153275-53-7; Chloroacetyl tetramethyl benzene
EINECS	Contact for details

Quality Control

Our Chloroacetyl-1,2,3,4-Tetramethylbenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance in cGMP and ISO 9001 environments for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.