Description

Hexestrol Diazirine is a synthetic, photoactivatable chemical probe derived from the estrogen analog hexestrol, designed for covalent cross-linking studies. This compound is critical for researchers investigating protein-ligand interactions, receptor mapping, and the structural dynamics of estrogen-related pathways. It serves as an essential tool for pharmaceutical R&D, academic biochemistry, and proteomics laboratories requiring high-purity, functionalized small molecules for advanced labeling techniques. The product is supplied as a light-sensitive material to preserve its photoreactive integrity.

Application

• Photoaffinity Labeling (PAL): A key reagent for covalently tagging estrogen receptors and other binding proteins to study interaction sites and mechanisms.
• Chemical Proteomics: Used in activity-based protein profiling (ABPP) to identify and characterize proteins that interact with estrogen-like structures.
• Drug Discovery Research: Employed in hit-to-lead optimization for developing targeted therapies by elucidating binding pockets and off-target effects.
• Structural Biology: Aids in the structural analysis of protein complexes through cross-linking mass spectrometry (XL-MS) workflows.
• Endocrinology Studies: Facilitates research into estrogen signaling pathways, receptor dimerization, and nuclear translocation events.
• Bioconjugation & Probe Development: Serves as a versatile building block for creating more complex diagnostic or therapeutic conjugates.

Basic Information

Product Name	Hexestrol Diazirine
CAS No.	153145-01-8
Molecular Formula	C20H22N2O2
Molecular Weight	322.41 g/mol
Synonyms	4,4'-(1,2-Diethyl-1,2-ethenediyl)bis[2-(3-methyl-3H-diazirin-3-yl)phenol]; Hexestrol Diazirine Probe; Diazirine-labeled Hexestrol; Photoactivatable Hexestrol; Estrogen Receptor Photoaffinity Probe; DES Diazirine Analog; (E)-4,4'-(1,2-Diethyl-1,2-ethenediyl)bis(2-(3-methyl-3H-diazirin-3-yl)phenol)
EINECS	Contact for details

Quality Control

Every batch of Hexestrol Diazirine is manufactured and tested under strict quality management protocols to ensure consistency and reliability for research applications. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry characterization. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with each shipment, supporting compliance with internal quality standards for advanced research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizers and bases.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.