Description

4-Iodo-2-Fluoro-3-Formylpyridine is a versatile and highly functionalized pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique combination of halogen and aldehyde substituents makes it an invaluable precursor for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, leveraging its halogenated pyridine core.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and coordination chemistry.
• Material Science Research: Employed in the synthesis of functional organic materials, including liquid crystals and organic semiconductors.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form biaryl systems.
• Derivatization and Library Synthesis: The reactive aldehyde group allows for further functionalization (e.g., condensation, reduction) to generate diverse compound libraries for high-throughput screening.

Basic Information

Product Name	4-Iodo-2-Fluoro-3-Formylpyridine
CAS No.	153034-82-3
Molecular Formula	C6H3FINO
Molecular Weight	266.99 g/mol
Synonyms	2-Fluoro-4-iodopyridine-3-carboxaldehyde; 3-Formyl-2-fluoro-4-iodopyridine; 4-Iodo-2-fluoronicotinaldehyde; 2-Fluoro-4-iodo-3-pyridinecarboxaldehyde; 153034-82-3; 4-Iodo-2-fluoro-3-pyridinecarbaldehyde
EINECS	Contact for details

Quality Control

Our 4-Iodo-2-Fluoro-3-Formylpyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere for long-term storage. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.