Description

2-Fluoro-4-Iodo-3-Picoline is a halogenated pyridine derivative of significant interest in advanced organic synthesis. This compound serves as a versatile and valuable building block for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. It is primarily sought after by research chemists and process development scientists for applications in medicinal chemistry, where its unique substitution pattern enables the introduction of both fluorine and iodine functionalities into target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of functionalized organic molecules for electronic materials and liquid crystals.
• Chemical Biology Probes: Utilized to develop molecular probes and tags for studying biological processes due to the reactivity of the iodine moiety.
• Custom Synthesis and Contract Manufacturing: A critical substrate for custom synthesis houses serving the life sciences industry.

Basic Information

Product Name	2-Fluoro-4-Iodo-3-Picoline
CAS No.	153034-80-1
Molecular Formula	C6H5FIN
Molecular Weight	237.02 g/mol
Synonyms	3-Picoline, 2-fluoro-4-iodo-; 2-Fluoro-4-iodo-3-methylpyridine; 4-Iodo-2-fluoro-3-methylpyridine; 3-Methyl-4-iodo-2-fluoropyridine; 2-Fluoro-4-iodo-3-picoline; 153034-80-1; FC1(C)I=C(C)N=CC=1
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Iodo-3-Picoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.