Description

3,4,5-Trifluorocinnamic Acid is a high-value fluorinated aromatic building block essential for advanced organic synthesis. Its unique trifluoromethyl-substituted cinnamate structure makes it a critical intermediate for developing novel pharmaceuticals and agrochemicals with enhanced metabolic stability and bioavailability. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating targeted bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of tyrosine kinase inhibitors, anti-inflammatory agents, and other small molecule drugs where the trifluoromethyl group modulates potency and ADME properties.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, leveraging fluorine's ability to improve lipophilicity and membrane permeability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated monomers and polymers used in electronic displays and organic light-emitting diodes (OLEDs) due to its impact on molecular alignment and electronic properties.
• Peptide Mimetics & Bio-conjugation: The carboxylic acid functionality allows for coupling reactions to create fluorinated peptide analogs or for use as a linker in bioconjugation and probe development.
• Chemical Research & Development: A versatile reagent for exploring novel fluorination chemistry, cross-coupling reactions (e.g., Heck reaction), and as a standard in analytical method development.
• Material Science Additive: Incorporated into specialty polymers and coatings to impart specific surface characteristics, such as oil and water repellency (fluorinated surfaces).

Basic Information

Product Name	3,4,5-Trifluorocinnamic Acid
CAS No.	152152-19-7
Molecular Formula	C9H5F3O2
Molecular Weight	202.13 g/mol
Synonyms	(E)-3-(3,4,5-Trifluorophenyl)acrylic Acid; 3-(3,4,5-Trifluorophenyl)-2-propenoic Acid; trans-3,4,5-Trifluorocinnamic Acid; 3,4,5-Trifluorocinnameic Acid; 3,4,5-Trifluorobenzeneacrylic Acid; β-(3,4,5-Trifluorophenyl)acrylic Acid
EINECS	Contact for details

Quality Control

Our 3,4,5-Trifluorocinnamic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements of research and process chemistry. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.