Description

4-Chloro-3-Fluoroacetophenone is a high-purity fluorinated aromatic ketone building block, essential for advanced organic synthesis. Its value lies in providing a versatile and reactive scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogenated motifs into their target structures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those containing fluorinated and chlorinated aromatic systems.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the difluoroacetophenone core imparts desired biological activity.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystal compounds used in display technologies.
• Organic Electronic Materials: Employed in the development of novel organic semiconductors and charge-transport materials.
• Chemical Research & Development: A versatile reagent for Suzuki, Heck, and other cross-coupling reactions to create complex biaryl structures.
• Fluorine Chemistry Studies: Used as a model compound in academic and industrial research exploring the effects of halogen substitution on reactivity and physical properties.

Basic Information

Product Name	4-Chloro-3-Fluoroacetophenone
CAS No.	151945-84-5
Molecular Formula	C8H6ClFO
Molecular Weight	172.58 g/mol
Synonyms	1-(4-Chloro-3-fluorophenyl)ethan-1-one; 4'-Chloro-3'-fluoroacetophenone; 3-Fluoro-4-chloroacetophenone; 4-Chloro-3-fluorophenyl methyl ketone; 1-Acetyl-4-chloro-3-fluorobenzene; p-Chloro-m-fluoroacetophenone; 4-Chloro-3-fluoroacetylbenzene
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Fluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.