Description

Aziridine, 1-Bromo-2,3-Dimethyl-, (2S,3S)- (9Ci) is a high-value, stereochemically defined aziridine derivative, a versatile and reactive three-membered heterocyclic building block. Its core value lies in its ability to act as a key chiral synthon for the stereoselective synthesis of complex nitrogen-containing molecules, enabling precise control over molecular architecture. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, specialty intermediates for constructing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors, kinase inhibitors, and other nitrogen-rich therapeutics.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where its aziridine ring can be opened to introduce specific functional groups into lead compounds.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for creating functional polymers with tailored properties, such as coatings, adhesives, or smart materials with responsive behavior.
• Organic Synthesis Reagent: Employed in academic and industrial R&D for cycloaddition reactions, nucleophilic ring-opening reactions, and as a precursor to other chiral amines and amino alcohols.
• Ligand & Catalyst Development: Utilized as a precursor for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis to produce enantiomerically pure compounds.
• Bioconjugation Chemistry: Potential use in modifying biomolecules (proteins, peptides) due to the reactivity of the aziridine ring with nucleophilic residues under controlled conditions.

Basic Information

Item	Detail
Product Name	Aziridine, 1-Bromo-2,3-Dimethyl-, (2S,3S)- (9Ci)
CAS No.	151413-98-8
Molecular Formula	C5H10BrN
Molecular Weight	164.04 g/mol
Synonyms	(2S,3S)-1-Bromo-2,3-dimethylaziridine; 1-Bromo-2,3-dimethylaziridine, (2S,3S)-; (2S,3S)-1-Bromo-2,3-dimethylethylenimine; 1-Bromo-2,3-dimethylazacyclopropane, (2S,3S)-; (2S,3S)-1-Bromo-2,3-dimethylaziridine (9CI); 1-Bromo-cis-2,3-dimethylaziridine; cis-1-Bromo-2,3-dimethylaziridine
EINECS	Contact for details

Quality Control

Our Aziridine, 1-Bromo-2,3-Dimethyl-, (2S,3S)- (9Ci) is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure high chemical and stereochemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing identity, purity (by HPLC/GC), chiral excess, and impurity profiles are provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Due to the reactive nature of the aziridine ring and the bromine substituent, the material should be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (2S,3S)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.