Description

N-(Trifluoromethanesulfonyl)trifluoroacetamide is a specialized fluorinated reagent and building block of significant interest in advanced organic synthesis. Its unique structure, featuring both a trifluoromethanesulfonyl (triflyl) and a trifluoroacetyl group, makes it a valuable precursor for introducing fluorinated moieties and for use in cyclization and coupling reactions. This high-purity intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for creating novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for introducing fluorinated groups to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where fluorination can improve efficacy and environmental profile.
• Organic Synthesis Reagent: Acts as a versatile reagent in academic and industrial laboratories for cyclization reactions, amide bond formation, and as a precursor to other trifluoromethylated compounds.
• Material Science Precursor: Employed in the development of specialty polymers and advanced materials that require fluorinated components for specific thermal or chemical resistance properties.
• Ligand and Catalyst Development: Useful in the synthesis of novel ligands and organocatalysts used in asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	N-(Trifluoromethanesulfonyl)trifluoroacetamide
CAS No.	151198-85-5
Molecular Formula	C4F6NO3S
Molecular Weight	280.10 g/mol
Synonyms	Trifluoro-N-(trifluoromethylsulfonyl)acetamide; N-(Triflyl)trifluoroacetamide; 2,2,2-Trifluoro-N-[(trifluoromethyl)sulfonyl]acetamide; TFTA; Tf2NCOCF3; Bis(trifluoromethylsulfonyl)amine derivative; Acetamide, 2,2,2-trifluoro-N-[(trifluoromethyl)sulfonyl]-
EINECS	Contact for details

Quality Control

Our N-(Trifluoromethanesulfonyl)trifluoroacetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Store away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.