Description

4-(1-Bromoethyl)-1,2-Difluorobenzene is a versatile fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound is valued for its dual functionality, featuring both a bromoethyl group and difluoro substitution on the benzene ring, which allows for selective and sequential chemical transformations. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the construction of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, leveraging the fluorine atoms to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides where the difluorobenzene moiety is a critical structural component.
• Ligand and Material Science: Serves as a starting material for the preparation of specialized ligands for catalysis and as a monomer or building block for advanced polymeric materials.
• Cross-Coupling Reactions: The bromoethyl side chain is an effective handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to introduce more complex fragments.
• Fluorine Chemistry Research: An important substrate for studying the effects of fluorine substitution patterns on chemical reactivity and physical properties in academic and industrial R&D settings.

Basic Information

Product Name	4-(1-Bromoethyl)-1,2-Difluorobenzene
CAS No.	150881-71-3
Molecular Formula	C8H7BrF2
Molecular Weight	221.04 g/mol
Synonyms	1-Bromo-1-(3,4-difluorophenyl)ethane; 1-(3,4-Difluorophenyl)-1-bromoethane; (1-Bromoethyl)-3,4-difluorobenzene; 3,4-Difluoro-α-bromoethylbenzene; α-Bromo-3,4-difluoroethylbenzene; 4-Bromoethyl-1,2-difluorobenzene; 150881-71-3
EINECS	Contact for details

Quality Control

Our 4-(1-Bromoethyl)-1,2-Difluorobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay and impurity profiles. We are committed to meeting the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.