Description

3-(Tritylthio)Propanal is a specialized organosulfur building block featuring a trityl-protected thiol group and an aldehyde functionality. This unique bifunctional structure makes it a valuable intermediate for synthesizing complex molecules, particularly in pharmaceutical research and fine chemical production. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for constructing novel drug candidates and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates, particularly those requiring thiol or disulfide linkages.
• Peptide Chemistry: Used in the preparation of cysteine analogs and for introducing protected thiol groups into peptide chains during solid-phase or solution-phase synthesis.
• Ligand and Catalyst Synthesis: Serves as a precursor for creating specialized ligands for metal catalysis or organocatalysts in asymmetric synthesis.
• Polymer Functionalization: Employed to introduce aldehyde and protected thiol handles onto polymer backbones for creating smart materials or bioconjugation platforms.
• Bioconjugation Reagent: The aldehyde group allows for selective conjugation to amines, while the trityl-protected thiol can be deprotected for further coupling, useful in antibody-drug conjugate (ADC) research.
• Chemical Biology Probes: Useful for synthesizing activity-based probes or affinity tags to study protein function and interactions.

Basic Information

Product Name	3-(Tritylthio)Propanal
CAS No.	150350-28-0
Molecular Formula	C22H20OS
Molecular Weight	332.46 g/mol
Synonyms	3-(Triphenylmethylthio)propanal; 3-[(Triphenylmethyl)thio]propanal; Propanal, 3-[(triphenylmethyl)thio]-; 3-(Tritylsulfanyl)propanal; NSC 339243; Tritylthiopropanal; S-Trityl-3-mercaptopropionaldehyde; 3-(Tritylmercapto)propionaldehyde
EINECS	Contact for details

Quality Control

Our 3-(Tritylthio)Propanal is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and GC for residual solvent analysis, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate to maximize shelf-life stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.