Description

3-(2-Chlorophenyl)-1,1,1-Trifluoro-2-Propanone is a high-value fluorinated aromatic ketone building block, recognized for its unique trifluoromethyl ketone moiety. This compound is essential for introducing the trifluoromethyl group into complex molecules, a modification that significantly enhances metabolic stability, lipophilicity, and bioavailability. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in CNS and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the CF3 group improves efficacy and environmental profile.
• Material Science Research: Serves as a precursor for specialty monomers and ligands used in catalysis and advanced polymer systems.
• Fluorine Chemistry: A versatile building block in organofluorine chemistry for creating complex fluorinated scaffolds in medicinal and synthetic chemistry.
• Chemical Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	3-(2-Chlorophenyl)-1,1,1-Trifluoro-2-Propanone
CAS No.	150322-79-5
Molecular Formula	C9H6ClF3O
Molecular Weight	222.59 g/mol
Synonyms	1-(2-Chlorophenyl)-3,3,3-trifluoropropan-1-one; 2-Chloro-α,α,α-trifluoroacetophenone; 2'-Chloro-α,α,α-trifluoroacetophenone; 3,3,3-Trifluoro-1-(2-chlorophenyl)-1-propanone; 2-Chlorophenyl trifluoromethyl ketone; α,α,α-Trifluoro-2-chloroacetophenone; 150322-79-5; 2-Chloro-α,α,α-trifluoroacetophenone
EINECS	Contact for details

Quality Control

Our 3-(2-Chlorophenyl)-1,1,1-Trifluoro-2-Propanone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices for research-grade chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.