Description

2-((4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Methyl)Benzonitrile is a high-value, synthetically versatile organoboron building block essential for modern cross-coupling chemistry. Its core value lies in the protected boronic ester group, which offers superior stability and handling characteristics compared to free boronic acids, facilitating complex multi-step syntheses. This compound is critically needed by R&D and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and CNS research.
• Agrochemical Synthesis: Used to create complex, functionalized aromatic compounds that serve as intermediates for advanced herbicides, fungicides, and insecticides.
• Ligand and Catalyst Development: Employed in the research and production of specialized ligands for catalysis and organometallic complexes.
• Material Science Research: Serves as a monomer or building block for developing organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology Probes: Utilized in the synthesis of bioconjugates and molecular probes for diagnostic and research applications.
• Custom Synthesis & Contract Manufacturing: A critical raw material for fine chemical and CDMO (Contract Development and Manufacturing Organization) facilities producing bespoke compounds for clients.

Basic Information

Product Name	2-((4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Methyl)Benzonitrile
CAS No.	149989-78-6
Molecular Formula	C14H18BNO2
Molecular Weight	243.11 g/mol
Synonyms	2-((4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)benzonitrile; 2-(Pinacolborylmethyl)benzonitrile; (2-Cyanobenzyl)boronic acid pinacol ester; Pinacol (2-cyanobenzyl)boronate; 2-(Bromomethyl)benzonitrile pinacol boronic ester (precursor); 2-(Pinacolatoborylmethyl)benzonitrile; α-(Pinacolboryl)-o-tolunitrile
EINECS	Contact for details

Quality Control

Our production of 2-((4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Methyl)Benzonitrile adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR (1H, 13C, 11B), and GC-MS, to confirm identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis of the boronic ester moiety. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.