Description

2-(3-Chloro-Propenyl)-1,4-Difluoro-Benzene is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where the introduction of fluorine atoms and reactive chloroalkenyl groups is crucial for modulating biological activity and material properties. Industries that require high-purity, custom synthetic intermediates for research and development, including pharmaceutical R&D, agrochemical manufacturing, and material science, are the primary users of this chemical.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders or possessing anti-inflammatory properties.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluorobenzene moiety enhances stability and bioavailability.
• Liquid Crystal & OLED Material Research: Acts as a building block for fluorinated organic semiconductors and liquid crystal compounds, contributing to improved electronic properties and device performance.
• Cross-Coupling Reactions: The chloroalkenyl group makes it a valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Heck, Suzuki) for constructing complex biaryl and conjugated systems.
• Custom Chemical Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific projects requiring fluorinated aromatic scaffolds.
• Polymer Modification: Can be incorporated into polymer backbones to impart specific characteristics like chemical resistance or altered refractive index.

Basic Information

Item	Details
Product Name	2-(3-Chloro-Propenyl)-1,4-Difluoro-Benzene
CAS No.	149946-42-9
Molecular Formula	C9H7ClF2
Molecular Weight	188.60 g/mol
Synonyms	1,4-Difluoro-2-(3-chloroprop-1-en-1-yl)benzene; 2-(3-Chloroprop-1-en-1-yl)-1,4-difluorobenzene; 1,4-Difluoro-2-(3-chloroallyl)benzene; 3-Chloro-1-(2,5-difluorophenyl)prop-1-ene; (3-Chloro-1-propenyl)-2,5-difluorobenzene; 2,5-Difluoro-β-chlorostyrene; 149946-42-9
EINECS	Contact for details

Quality Control

Every batch of 2-(3-Chloro-Propenyl)-1,4-Difluoro-Benzene is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including GC, HPLC, and NMR, is performed to verify identity, purity, and impurity profiles. A Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 2°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.