Description

3-Cyclobutene-1,2-Dicarboxylicacid,Monomethylester,(1S-Trans)-(9Ci) is a high-purity, stereochemically defined chiral synthon of significant value in advanced organic synthesis. Its rigid cyclobutene core and functionalized dicarboxylate moiety make it a versatile and sought-after building block for constructing complex molecular architectures. This compound is primarily utilized by research institutions and pharmaceutical development teams working on novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials. Its defined stereochemistry ensures predictable outcomes in asymmetric synthesis, which is critical for producing enantiomerically pure compounds.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Research: Used in developing advanced herbicides and pesticides with specific stereochemical activity.
• Ligand and Catalyst Synthesis: Serves as a backbone for creating novel chiral ligands and organocatalysts used in asymmetric catalysis.
• Material Science: A monomer or cross-linking agent in the research of polymers with specific optical or mechanical properties.
• Academic & Process Chemistry: Employed in methodological studies and scale-up process development for complex organic molecules.
• Fine Chemical Production: Integral to the multi-step synthesis of high-value, low-volume specialty chemicals.

Basic Information

Product Name	3-Cyclobutene-1,2-Dicarboxylicacid,Monomethylester,(1S-Trans)-(9Ci)
CAS No.	149883-21-6
Molecular Formula	C8H8O4
Molecular Weight	168.15 g/mol
Synonyms	(1S,2S)-3-Cyclobutene-1,2-dicarboxylic acid monomethyl ester; (1S-trans)-3-Cyclobutene-1,2-dicarboxylic Acid Monomethyl Ester; Monomethyl (1S,2S)-3-cyclobutene-1,2-dicarboxylate; trans-(1S,2S)-3-Cyclobutene-1,2-dicarboxylic Acid Methyl Ester; (1S,2S)-1-Methoxycarbonyl-3-cyclobutene-2-carboxylic Acid; 149883-21-6; (1S,2S)-1-(Methoxycarbonyl)-3-cyclobutene-2-carboxylic Acid
EINECS	Contact for details

Quality Control

Our 3-Cyclobutene-1,2-Dicarboxylicacid,Monomethylester,(1S-Trans)-(9Ci) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to confirm identity, strength, and composition. Certificates of Analysis (COA) detailing all specifications and test results are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.