Description

L-Proline, 1-Formyl-4-Hydroxy-, Methyl Ester, trans- (9Ci) is a high-purity, specialty proline derivative with a defined stereochemistry, serving as a critical chiral building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and bioactive peptides. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of peptidomimetics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for protease inhibitors and other targeted therapies.
• Peptidomimetic Synthesis: Used to introduce constrained proline analogs into peptide chains to enhance metabolic stability and biological activity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore novel chemical spaces and optimize lead compounds.
• Asymmetric Synthesis: Serves as a starting material or auxiliary in catalytic asymmetric reactions to create enantiomerically pure compounds.
• Bioconjugation & Probe Development: Useful for creating labeled compounds or conjugates for biochemical and diagnostic applications due to its functional groups.
• Academic & Institutional R&D: A valuable reagent for universities and research institutes exploring new synthetic methodologies and bioorganic chemistry.

Basic Information

Product Name	L-Proline, 1-Formyl-4-Hydroxy-, Methyl Ester, trans- (9Ci)
CAS No.	149882-41-7
Molecular Formula	C7H11NO4
Molecular Weight	173.17 g/mol
Synonyms	(2S,4R)-1-Formyl-4-hydroxyproline methyl ester; Methyl (2S,4R)-1-formyl-4-hydroxy-L-prolinate; trans-4-Hydroxy-L-proline methyl ester 1-carboxaldehyde; L-Proline, 1-formyl-4-hydroxy-, methyl ester, (4R)-; (4R)-1-Formyl-4-hydroxy-L-proline methyl ester; 1-Formyl-trans-4-hydroxy-L-proline methyl ester; A proline derivative for peptidomimetics
EINECS	Contact for details

Quality Control

Our L-Proline, 1-Formyl-4-Hydroxy-, Methyl Ester, trans- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.