Description

(5R-Cis)-Toluene-4-Sulfonic Acid 5-(2,4-Difluorophenyl)-5-(1H-1,2,4-Triazol-1-Yl)Methyltetrahydrofuran-3-Ylmethyl Ester is a high-purity, non-racemic chiral intermediate of significant importance in advanced pharmaceutical synthesis. Its precise stereochemistry and functional groups make it a critical building block for constructing complex active pharmaceutical ingredients (APIs). This compound is primarily needed by research institutions and manufacturers in the pharmaceutical industry, particularly those developing and producing antifungal and other specialized therapeutic agents.

Application

• Key Intermediate in Antifungal API Synthesis: Serves as a crucial precursor in the manufacturing of triazole-based antifungal drugs, such as Voriconazole and related compounds.
• Pharmaceutical Research & Development (R&D): Used in medicinal chemistry for the discovery and optimization of new therapeutic candidates targeting fungal infections.
• Process Chemistry & Scale-Up: Employed in developing and optimizing robust, scalable synthetic routes for commercial pharmaceutical production.
• Asymmetric Synthesis: Utilized in chiral synthesis due to its defined (5R-Cis) configuration to impart specific stereochemistry in final drug molecules.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and regulatory testing of finished APIs.
• Custom Synthesis: Acts as a starting material for the custom synthesis of novel, structurally related compounds for biological screening.

Basic Information

Product Name	(5R-Cis)-Toluene-4-Sulfonic Acid 5-(2,4-Difluorophenyl)-5-(1H-1,2,4-Triazol-1-Yl)Methyltetrahydrofuran-3-Ylmethyl Ester
CAS No.	149809-43-8
Molecular Formula	C22H22F2N3O4S
Molecular Weight	462.49 g/mol
Synonyms	(5R-Cis)-5-(2,4-Difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydro-3-furanyl 4-methylbenzenesulfonate; Voriconazole Intermediate; (5R,3R)-Tosylate Voriconazole Intermediate; 5-(2,4-Difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydro-3-furanyl 4-methylbenzenesulfonate (5R-cis)-; UK-109496 Tosylate Intermediate; (2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol Tosylate Precursor
EINECS	Contact for details

Quality Control

Our (5R-Cis)-Toluene-4-Sulfonic Acid 5-(2,4-Difluorophenyl)-5-(1H-1,2,4-Triazol-1-Yl)Methyltetrahydrofuran-3-Ylmethyl Ester is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity suitable for pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ICH Q7 guidelines for active pharmaceutical ingredients (APIs).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (5R-Cis isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.