Description

(S)-n-Boc-Pyrrolidin-2-Ylboronic Acid CAS NO 149716-79-0 is a high-purity, chiral boronic acid derivative, a critical building block in modern pharmaceutical synthesis. Its value lies in enabling the precise construction of complex molecules through efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries developing new active ingredients, particularly for chiral drug candidates and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in protease inhibitors and other biologically active molecules.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid coupling partner for the formation of carbon-carbon bonds in complex organic synthesis.
• Chiral Building Block: Used in the asymmetric synthesis of pyrrolidine-containing compounds, which are common scaffolds in medicinal chemistry.
• Process Research & Development (R&D): Employed in route scouting and optimization for the scalable production of novel chemical entities.
• Agrochemical Synthesis: Utilized in the research and development of new, more effective crop protection agents.
• Ligand and Catalyst Development: Acts as a precursor for creating novel chiral ligands and organoboron catalysts.

Basic Information

Product Name	(S)-n-Boc-Pyrrolidin-2-Ylboronic Acid
CAS No.	149716-79-0
Molecular Formula	C9H18BNO4
Molecular Weight	215.06 g/mol
Synonyms	(S)-1-(tert-Butoxycarbonyl)-2-boronic acid pyrrolidine; (S)-1-Boc-2-boronopyrrolidine; (S)-2-Borono-1-(tert-butoxycarbonyl)pyrrolidine; (S)-N-Boc-2-pyrrolidineboronic Acid; tert-Butyl (2S)-2-boronopyrrolidine-1-carboxylate; (S)-1-Boc-pyrrolidine-2-boronic acid; (S)-N-Boc-pyrrolidine-2-boronic acid; (S)-1-(tert-Butyloxycarbonyl)-2-boronopyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-n-Boc-Pyrrolidin-2-Ylboronic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic (moisture-sensitive) nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.