Description

(R)-n-Boc-Pyrrolidin-2-Ylboronic Acid CAS NO 149716-78-9 is a high-purity, enantiomerically pure boronic acid derivative, a critical chiral building block in modern synthetic chemistry. Its primary value lies in enabling the stereoselective synthesis of complex molecules, particularly through Suzuki-Miyaura cross-coupling reactions. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, as well as in advanced material science applications.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of active pharmaceutical ingredients (APIs), especially in creating novel protease inhibitors, neurological agents, and other small molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling: Serves as a crucial boron-containing partner in palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds with high stereochemical fidelity.
• Agrochemical Synthesis: Used in the development of enantiomerically pure pesticides and herbicides where specific stereochemistry is required for optimal biological activity.
• Ligand and Catalyst Development: Acts as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology & Proteomics: Employed in the synthesis of activity-based probes and other chemical tools for studying biological systems.
• Material Science Research: Utilized in the synthesis of chiral polymers and advanced organic materials with specific optical or electronic properties.

Basic Information

Product Name	(R)-n-Boc-Pyrrolidin-2-Ylboronic Acid
CAS No.	149716-78-9
Molecular Formula	C9H18BNO4
Molecular Weight	215.06 g/mol
Synonyms	(R)-1-Boc-2-pyrrolidineboronic acid; (R)-1-(tert-Butoxycarbonyl)-2-pyrrolidineboronic acid; (R)-N-Boc-2-pyrrolidineboronic acid; (R)-2-Borono-1-N-Boc-pyrrolidine; (R)-1-Boc-pyrrolidine-2-boronic acid; tert-Butyl (R)-2-boronopyrrolidine-1-carboxylate; (R)-N-Boc-pyrrolidin-2-ylboronic acid
EINECS	Contact for details

Quality Control

Every batch of our (R)-n-Boc-Pyrrolidin-2-Ylboronic Acid undergoes rigorous analytical testing to ensure it meets the stringent requirements for chiral intermediates. Our standard quality protocol includes chiral HPLC for enantiomeric excess (ee) verification, NMR for structural confirmation, and purity assessment. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality management system is designed to support cGMP and ISO standards for reliable, batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability and purity. For long-term storage, desiccants are recommended.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.