Description

(1R,2R,3S,5R)-Pinanediol Pyrrolidine-2R-Boronate Hydrochloride is a high-purity, chiral organoboron reagent, specifically a protected boronic ester derivative. This compound is a critical chiral building block and catalyst precursor in modern asymmetric synthesis, enabling the formation of carbon-carbon bonds with high stereoselectivity. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for developing active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Asymmetric Synthesis: A key chiral auxiliary and catalyst precursor for Suzuki-Miyaura and other transition-metal-catalyzed cross-coupling reactions.
• Pharmaceutical Intermediate: Used in the research and production of chiral drug candidates, particularly for CNS (Central Nervous System) and oncology targets.
• Agrochemical Development: Employed in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Ligand Synthesis: Serves as a precursor for sophisticated chiral ligands used in homogeneous catalysis.
• Material Science Research: Utilized in the development of chiral polymers and organic electronic materials.
• Academic & Process R&D: A valuable reagent for method development and scaling up stereoselective synthetic routes in laboratory and pilot plant settings.

Basic Information

Product Name	(1R,2R,3S,5R)-Pinanediol Pyrrolidine-2R-Boronate Hydrochloride
CAS No.	149716-72-3
Molecular Formula	C15H27BClNO2
Molecular Weight	299.64 g/mol
Synonyms	(1R,2R,3S,5R)-(-)-Pinanediol (R)-1-(Pyrrolidin-2-yl)boronate Hydrochloride; (R)-1-(2-Pyrrolidinyl)boronic Acid Pinanediol Ester Hydrochloride; (R)-(-)-1-(2-Pyrrolidinyl)boronic Acid Pinanediol Ester Hydrochloride; (R)-2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolidine Hydrochloride (Pinanediol Protected Analog); (R)-α-Pyrrolidinylboronic Acid Pinanediol Ester HCl; Chiral Pyrrolidine Boronate Ester HCl Salt
EINECS	Contact for details

Quality Control

Every batch of our (1R,2R,3S,5R)-Pinanediol Pyrrolidine-2R-Boronate Hydrochloride is manufactured under strict quality control protocols to ensure high chiral purity and chemical integrity, suitable for demanding synthetic applications. Our products undergo rigorous analytical testing, including chiral HPLC, NMR, and elemental analysis, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and during weighing to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.