Description

2-Borono-1-Pyrrolidinecarboxylicacid1-(1,1-Dimethylethyl)Ester is a high-value organoboron compound, specifically a protected boronic acid ester derivative of proline. This chemical is a critical building block in modern synthetic chemistry, prized for its role in facilitating carbon-carbon bond formation. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting protease inhibition.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a vital organoboron reagent for constructing biaryl and other complex molecular architectures.
• Peptidomimetic Research: Used in the design and synthesis of peptide analogs with enhanced metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block due to its proline-derived stereogenic center.
• Agrochemical Development: Intermediate in the research and production of advanced crop protection agents.
• Material Science: Building block for advanced organic electronic materials and polymers.

Basic Information

Product Name	2-Borono-1-Pyrrolidinecarboxylicacid1-(1,1-Dimethylethyl)Ester
CAS No.	149682-75-7
Molecular Formula	C9H18BNO4
Molecular Weight	215.06 g/mol
Synonyms	N-Boc-2-Boronoproline; (S)-1-(tert-Butoxycarbonyl)-2-boronic acid pyrrolidine; tert-Butyl (S)-2-boronopyrrolidine-1-carboxylate; (S)-1-Boc-2-boronopyrrolidine; Proline, 2-borono-, 1-(1,1-dimethylethyl) ester; N-Boc-L-2-boronoproline; (S)-2-Borono-1-(tert-butoxycarbonyl)pyrrolidine; 2-Boronoproline tert-butyl ester
EINECS	Contact for details

Quality Control

Our 2-Borono-1-Pyrrolidinecarboxylicacid1-(1,1-Dimethylethyl)Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and enantiomeric excess where specified. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.