Description

4''-Butyl-4-Bromo-3-Fluorobiphenyl is a high-purity, advanced organic intermediate characterized by its biphenyl core with strategically positioned bromo, fluoro, and butyl substituents. This compound is of significant commercial value for its role in the synthesis of complex molecules, particularly in the pharmaceutical and advanced materials sectors. It is primarily sought after by R&D chemists and process development scientists in the agrochemical, liquid crystal, and pharmaceutical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders or possessing anti-inflammatory properties.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides, where the biphenyl structure contributes to biological activity.
• Liquid Crystal Materials: Serves as a core component in the production of advanced liquid crystal compounds for display technologies, leveraging its rigid biphenyl structure and halogen substituents.
• Organic Light-Emitting Diodes (OLEDs): Acts as a precursor or host material in the development of electron-transport or emissive layers for OLED devices.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive bromine atom, enabling the construction of complex conjugated systems.
• Chemical Research & Development: Employed in academic and industrial R&D labs as a versatile synthon for exploring new chemical spaces and developing novel synthetic methodologies.

Basic Information

Product Name	4''-Butyl-4-Bromo-3-Fluorobiphenyl
CAS No.	149451-95-6
Molecular Formula	C₁₆H₁₆BrF
Molecular Weight	307.20 g/mol
Synonyms	4-Butyl-4'-Bromo-3'-Fluorobiphenyl; 3'-Fluoro-4-butyl-4'-bromobiphenyl; 1-Bromo-2-fluoro-4'-(4-butylphenyl)benzene; 4-Bromo-3-fluorophenyl 4-butylphenyl ketone (precursor related); Biphenyl, 4-butyl-4'-bromo-3'-fluoro-; [1,1'-Biphenyl]-4-carbonitrile, 4'-butyl-3-fluoro- (related nitrile); 4'-Butyl-3-fluoro-4-bromobiphenyl
EINECS	Contact for details

Quality Control

Our 4''-Butyl-4-Bromo-3-Fluorobiphenyl is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent batch-to-batch quality. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We adhere to cGMP guidelines where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light) and should be handled under an inert atmosphere for prolonged storage to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.