Description

Boronic Acid, [5-Methoxy-1-[(4-Methylphenyl)Sulfonyl]-1H-Indol-3-Yl]- is a specialized organoboron compound featuring a sulfonyl-protected indole core. This molecule is a critical synthetic intermediate valued for its role in cross-coupling reactions, enabling the efficient construction of complex chemical architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and advanced materials sectors for drug discovery and the synthesis of novel organic compounds. The compound, identified by CAS number 149108-62-3, is supplied to meet the stringent purity and consistency demands of modern chemical synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those targeting neurological and oncological pathways.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic acid coupling partner for the formation of carbon-carbon bonds, a fundamental transformation in medicinal chemistry.
• Chemical Biology & Proteomics: Used in the development of molecular probes and inhibitors to study enzyme function and protein-protein interactions.
• Advanced Materials Research: Employed in the synthesis of organic semiconductors, liquid crystals, and polymers with tailored electronic or photophysical properties.
• Process Chemistry & Scale-Up: Supports route scouting and optimization for the commercial-scale manufacturing of complex molecules.
• Academic & Industrial R&D: A valuable reagent for exploratory synthesis in university and corporate research laboratories focused on heterocyclic and organometallic chemistry.

Basic Information

Product Name	Boronic Acid, [5-Methoxy-1-[(4-Methylphenyl)Sulfonyl]-1H-Indol-3-Yl]-
CAS No.	149108-62-3
Molecular Formula	C17H17BNO5S
Molecular Weight	358.20 g/mol
Synonyms	[5-Methoxy-1-(4-methylphenyl)sulfonyl-1H-indol-3-yl]boronic acid; 3-Borono-5-methoxy-1-(p-tolylsulfonyl)indole; 1-(4-Methylbenzenesulfonyl)-5-methoxy-1H-indole-3-boronic acid; 5-Methoxy-1-tosyl-1H-indole-3-boronic acid; 5-Methoxy-1-(p-toluenesulfonyl)indole-3-boronic acid; Boronic acid, B-[5-methoxy-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]-; 149108-62-3
EINECS	Contact for details

Quality Control

Our Boronic Acid, [5-Methoxy-1-[(4-Methylphenyl)Sulfonyl]-1H-Indol-3-Yl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support cGMP and ISO standards for pharmaceutical and research applications, ensuring reliable performance in your critical synthetic workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.