Description

4'-Hydroxy-3'-(Trifluoromethyl)Acetophenone is a high-purity trifluoromethylated acetophenone derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a phenolic hydroxyl and a trifluoromethyl group, makes it a versatile intermediate for creating compounds with enhanced biological activity and physicochemical properties. This product is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to synthesize novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used to develop advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve efficacy and environmental stability.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated organic electronic materials, contributing to improved performance in displays and lighting.
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to create specialty polymers with unique thermal, optical, or surface properties.
• Chemical Research & Development: A valuable scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Dye & Pigment Intermediate: Used in the synthesis of specialized fluorinated dyes and pigments for high-performance applications.

Basic Information

Product Name	4'-Hydroxy-3'-(Trifluoromethyl)Acetophenone
CAS No.	149105-11-3
Molecular Formula	C9H7F3O2
Molecular Weight	204.15 g/mol
Synonyms	1-[4-Hydroxy-3-(trifluoromethyl)phenyl]ethanone; 3'-Trifluoromethyl-4'-hydroxyacetophenone; 4'-Hydroxy-3'-trifluoromethylacetophenone; 1-(4-Hydroxy-3-(trifluoromethyl)phenyl)ethan-1-one; 3-(Trifluoromethyl)-4-hydroxyacetophenone; 4-Hydroxy-α,α,α-trifluoro-m-acetophenone; 4-Hydroxy-3-trifluoromethylacetophenone; HTA
EINECS	Contact for details

Quality Control

Our 4'-Hydroxy-3'-(Trifluoromethyl)Acetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.